Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203766 | 0.83 | CXCR1 (0.44) | MAPTCXCR1CXCR2SMN1; SMN2 | |
| SCHEMBL1203027 | 0.81 | NTRK1 (0.48) | PPARABRD4TGFBR1MAPTCXCR1 | |
| SCHEMBL1202935 | 0.77 | P4HTM (0.47) | PPARAKDM5AKDM4CKDM5BMAPT | |
| SCHEMBL19554501 | 0.70 | NPC1 (0.43) | TGFBR1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL15630537 | 0.70 | TRPM8 (0.51) | PPARAKDM2BTRPM8CXCR1CXCR2 | |
| SCHEMBL12983447 | 0.69 | AGTR1 (0.42) | PPARAKDM5AKDM4CKDM5BKDM2B | |
| SCHEMBL2903422 | 0.69 | MMP13 (0.43) | PPARAP4HTM | |
| SCHEMBL19613847 | 0.69 | NTRK1 (0.39) | TGFBR1MAPTKDM4E | |
| SCHEMBL1202379 | 0.68 | NTRK1 (0.47) | MAPTKDM4EPTPN1TDP1POLB | |
| SCHEMBL1202088 | 0.67 | FYN (0.63) | KDM4EP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |