Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 16/20 | 0.47 |
| ▸ | FAP | Q12884 | 5/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12949922 | 0.89 | PREP (0.54) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288977 | 0.88 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL12031716 | 0.87 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8287698 | 0.87 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8287708 | 0.87 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL16281614 | 0.85 | PREP (0.60) | PREPFAPDPP4P2RX7 | |
| SCHEMBL8288835 | 0.84 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288969 | 0.84 | PREP (0.49) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8286847 | 0.84 | RAB9A (0.55) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8286843 | 0.83 | PREP (0.44) | PREPFAPDPP8DPP9DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725548-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF ASPARTIC ACETAL CASPASE INHIBITORS | VERTEX PHARMA (US) | 2015-01-14 | — | — | EP | disclosed |
| EP-2399915-A1 | Process and intermediates for the preparation of aspartic acetal caspase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-28 | — | — | EP | disclosed |