Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 15/20 | 0.47 |
| ▸ | FAP | Q12884 | 5/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12031716 | 0.89 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL12949922 | 0.89 | PREP (0.54) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288913 | 0.89 | PREP (0.50) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288977 | 0.88 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL12031852 | 0.87 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8287722 | 0.87 | TAS1R3 (0.50) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288969 | 0.86 | PREP (0.49) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL12031643 | 0.85 | PREP (0.51) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL12949982 | 0.85 | PREP (0.60) | PREPFAPDPP8DPP9DPP4 | |
| SCHEMBL8288835 | 0.84 | PREP (0.47) | PREPFAPDPP8DPP9DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399916-A1 | Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2005085236-A2 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-09-15 | — | — | WO | disclosed |