Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 10/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | APP | P05067 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954688 | 0.88 | RAB9A (0.54) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| Methane SCHEMBL28056221 | 0.80 | RAB9A (0.64) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4972074 | 0.80 | CYP19A1 (0.46) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL827403 | 0.78 | RAB9A (0.67) | NPC1RAB9AKDM4EALDH1A1MEN1 | |
| Hydrogen Sulfide SCHEMBL16859912 | 0.76 | RAB9A (0.64) | NPC1RAB9AKDM4EALDH1A1MEN1 | |
| Hydrogen Sulfide SCHEMBL28205214 | 0.76 | RAB9A (0.64) | NPC1RAB9AKDM4EALDH1A1MEN1 | |
| SCHEMBL3738535 | 0.76 | CYP19A1 (0.58) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3073946 | 0.75 | RAB9A (0.69) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL18830943 | 0.75 | NPC1 (0.57) | CYP19A1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL13078668 | 0.74 | KDM4E (0.54) | CYP19A1NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102036972-A | Treatment of duchenne muscular dystrophy | SUMMIT CORP PLC | 2011-04-27 | — | — | CN | disclosed |
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| WO-2009021750-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-02-19 | — | — | WO | disclosed |
| EP-1261607-B1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-12 | — | — | EP | disclosed |
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-7105550-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-12 | — | — | US | disclosed |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER3 | CYP19A1 876/4885NPC1 1418/4885RAB9A 3507/4885 |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER1 | CYP19A1 986/4885NPC1 799/4885RAB9A 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.