Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 5/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.37 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203676 | 0.92 | HDAC3 (0.43) | CTNNB1TCF7L2FLT1KDRMAPT | |
| SCHEMBL1202812 | 0.87 | PIM1 (0.49) | MMP13ALDH1A1NTRK1PIM1 | |
| SCHEMBL1203014 | 0.85 | DHODH (0.41) | CTNNB1TCF7L2ALDH1A1MAPTKDM4E | |
| SCHEMBL2903422 | 0.85 | MMP13 (0.43) | CTNNB1TCF7L2MMP13MMP10MMP8 | |
| SCHEMBL1203133 | 0.84 | DDR2 (0.47) | CTNNB1TCF7L2KITDDR2NTRK1 | |
| SCHEMBL1203391 | 0.83 | ALDH1A1 (0.46) | CTNNB1TCF7L2ALDH1A1MAPTNPSR1 | |
| SCHEMBL1203791 | 0.83 | ALDH1A1 (0.46) | CTNNB1TCF7L2ALDH1A1MAPTNPSR1 | |
| SCHEMBL1202844 | 0.83 | CTNNB1 (0.47) | CTNNB1TCF7L2ALDH1A1MAPTNPSR1 | |
| SCHEMBL1202030 | 0.82 | ALDH1A1 (0.44) | CTNNB1TCF7L2KITDDR2ALDH1A1 | |
| SCHEMBL1203647 | 0.81 | FLT1 (0.41) | KITDDR2ALDH1A1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | CTNNB1 2021/4885TCF7L2 2808/4885MMP13 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.