Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MMP10 | P09238 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905633 | 0.91 | HDAC3 (0.46) | HDAC3HDAC1HDAC2FYNHDAC6 | |
| SCHEMBL1202935 | 0.89 | P4HTM (0.47) | PPARAP4HTMFYN | |
| SCHEMBL2905868 | 0.85 | FYN (0.50) | MMP13NTRK1FYN | |
| SCHEMBL1204006 | 0.85 | CTNNB1 (0.41) | MMP13MMP10MMP8CTNNB1TCF7L2 | |
| SCHEMBL2903393 | 0.83 | KDM4E (0.47) | PPARAVNN1CHRM4FYN | |
| SCHEMBL1203133 | 0.79 | DDR2 (0.47) | CTNNB1TCF7L2NTRK1 | |
| SCHEMBL2907129 | 0.78 | HDAC3 (0.44) | HDAC3HDAC1HDAC2VNN1NTRK1 | |
| SCHEMBL1202030 | 0.77 | ALDH1A1 (0.44) | CTNNB1TCF7L2P4HTM | |
| SCHEMBL1203676 | 0.77 | HDAC3 (0.43) | HDAC3HDAC1HDAC2CTNNB1TCF7L2 | |
| SCHEMBL1203106 | 0.75 | NTRK1 (0.49) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |