Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.49 |
| ▸ | CASP4 | P49662 | 1/20 | 0.49 |
| ▸ | CASP5 | P51878 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CASP9 | P55211 | 1/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.49 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18620597 | 0.87 | ACE (0.60) | PREPCASP1CASP3CASP2CASP4 | |
| SCHEMBL9814469 | 0.87 | CAPN1 (0.59) | PREPCASP1CASP3CASP7CASP8 | |
| SCHEMBL20484674 | 0.87 | ACE (0.60) | PREPCASP1CASP3CASP2CASP4 | |
| SCHEMBL9814470 | 0.87 | CAPN1 (0.59) | PREPCASP1CASP3CASP7CASP8 | |
| SCHEMBL10607790 | 0.86 | PREP (0.71) | PREPACEALDH1A1CYP3A4TSHR | |
| SCHEMBL10607793 | 0.86 | PREP (0.71) | PREPACEALDH1A1CYP3A4TSHR | |
| SCHEMBL22209492 | 0.85 | ALDH1A1 (0.61) | PREPCASP1CASP3CASP2CASP4 | |
| SCHEMBL18620865 | 0.85 | ALDH1A1 (0.61) | PREPCASP1CASP3CASP2CASP4 | |
| SCHEMBL12023625 | 0.83 | ALDH1A1 (0.53) | PREPCASP1CASP3CASP2CASP4 | |
| SCHEMBL478151 | 0.83 | ALDH1A1 (0.53) | PREPCASP1CASP3CASP2CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329662-B2 | Prodrug of an ICE inhibitor | Vertexd Pharmaceuticals Incorporated (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110301096-A1 | PRODRUG OF AN ICE INHIBITOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-08 | — | — | US | disclosed |
| US-7381827-B2 | 5-Ethoxy-4-(1-(benzyloxycarbonyl)-2-pyrrolidinylcarbonylamino)-5H-furan-2-one; purification by chromatography, selectively crystallization, or dynamic crystallization; useful for preparing caspase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301096-A1 | PRODRUG OF AN ICE INHIBITOR | CASP1, MCL1, IL1B | PREP 455/4885CASP1 1/4885CASP3 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.