Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1724728 | 0.99 | SLC6A2 (0.45) | SLC6A2SLC6A3HTR1AHSPB1CYP19A1 | |
| Trifluoroacetic Acid SCHEMBL2253892 | 0.91 | KDM1A (0.41) | SLC6A2SLC6A3HTR1AHSPB1CYP19A1 | |
| SCHEMBL22042142 | 0.90 | HSPB1 (0.49) | SLC6A2SLC6A3HSPB1CYP19A1CYP2D6 | |
| SCHEMBL22069557 | 0.87 | CYP19A1 (0.55) | HSPB1CYP19A1CYP2D6ALDH1A1MEN1 | |
| SCHEMBL26128371 | 0.87 | CYP19A1 (0.52) | HSPB1CYP19A1CYP2D6ALDH1A1MEN1 | |
| SCHEMBL2587459 | 0.86 | HSPB1 (0.46) | SLC6A2SLC6A3HTR1AHSPB1ALDH1A1 | |
| SCHEMBL31203065 | 0.83 | ALDH1A1 (0.47) | SLC6A2SLC6A3HTR1ACYP19A1CYP2D6 | |
| SCHEMBL3973922 | 0.83 | UTS2R (0.52) | CYP19A1CYP2D6ALDH1A1MEN1PTGES | |
| SCHEMBL12075923 | 0.83 | UTS2R (0.51) | SLC6A2SLC6A3CYP19A1CYP2D6ALDH1A1 | |
| SCHEMBL18066909 | 0.83 | CYP19A1 (0.44) | SLC6A2SLC6A3HTR1ACYP19A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019022223-A1 | CYCLIC AMINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | 東レ株式会社 | 2019-01-31 | — | — | WO | disclosed |
| US-20110319392-A1 | Thiazole Sulfonamide And Oxazole Sulfonamide Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-12-29 | — | — | US | disclosed |
| US-20110190280-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-08-04 | — | — | US | disclosed |
| WO-2009032667-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190280-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | SLC6A2 4755/4885SLC6A3 4335/4885HTR1A 4314/4885 |
| US-20110319392-A1 | Thiazole Sulfonamide And Oxazole Sulfonamide Kinase Inhibitors | STK24, MAP3K5, MAP3K2 | SLC6A2 3909/4885SLC6A3 3010/4885HTR1A 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.