Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.30 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14053633 | 0.98 | NPC1 (0.33) | NPC1RAB9APRMT5WDR77GPR139 | |
| SCHEMBL20226852 | 0.83 | DDR1 (0.36) | NPC1RAB9APRMT5WDR77GPR139 | |
| SCHEMBL2868846 | 0.78 | KDM4E (0.38) | NPC1RAB9APRMT5WDR77ABL1 | |
| SCHEMBL1203406 | 0.77 | NPC1 (0.35) | NPC1RAB9APRMT5WDR77GPR139 | |
| SCHEMBL16324761 | 0.77 | TGFBR1 (0.41) | — | |
| SCHEMBL16392314 | 0.77 | NPC1 (0.38) | NPC1RAB9APRMT5WDR77ABL1 | |
| SCHEMBL6112768 | 0.76 | NPC1 (0.55) | NPC1RAB9ASLC27A1KITDDR1 | |
| SCHEMBL20226862 | 0.73 | ABL1 (0.34) | NPC1RAB9APRMT5WDR77GPR139 | |
| SCHEMBL20223635 | 0.73 | GPR139 (0.34) | NPC1RAB9APRMT5WDR77GPR139 | |
| SCHEMBL17837095 | 0.73 | TGFBR1 (0.42) | NPC1RAB9AABL1KITBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| EP-1261607-B1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-12 | — | — | EP | disclosed |
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-7105550-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-12 | — | — | US | disclosed |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-30 | — | — | US | disclosed |
| EP-1261607-A1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001064674-A1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER3 | NPC1 1418/4885RAB9A 3507/4885PRMT5 1521/4885 |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER1 | NPC1 799/4885RAB9A 3677/4885PRMT5 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.