SCHEMBL120449

SCHEMBL120449

O=C1C=C(N(CCF)Cc2ccc(Cl)nc2)CO1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
ALDH1A1 P00352 1/20 0.32
PSEN1 P49768 1/20 0.31
PSEN2 P49810 1/20 0.31
APH1B Q8WW43 1/20 0.31
NCSTN Q92542 1/20 0.31
APH1A Q96BI3 1/20 0.31
PSENEN Q9NZ42 1/20 0.31
KDM1A O60341 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29845433 0.93 PSEN1 (0.31) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL502076 0.93 PSEN1 (0.31) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL1800501 0.88 CHRNA1 (0.32) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL1801176 0.88 ALDH1A1 (0.34) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL1796525 0.86 PSEN1 (0.31) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL14995919 0.86
SCHEMBL28892254 0.86 MDM2 (0.34) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL1165136 0.86 CHRNA1 (0.32) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4
SCHEMBL120881 0.86 PARP1 (0.32)
SCHEMBL15336350 0.86 CHRNA1 (0.32) CHRNA1CHRNB2CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4275493-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING GLYCOL ETHER SOLVENTS Bayer Aktiengesellschaft (DE) 2023-11-15 EP claimed
CN-108658816-B N-aryl amidine substituted trifluoroethyl sulfide derivatives useful as acaricides and insecticides 拜尔农作物科学股份公司 2023-05-02 CN claimed
US-20230068010-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING GLYCOL ETHER SOLVENTS BAYER AKTIENGESELLSCHAFT (DE) 2023-03-02 US claimed
EP-4040962-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING GLYCOL ETHER SOLVENTS Bayer Aktiengesellschaft (DE) 2022-08-17 EP claimed
WO-2021069628-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING GLYCOL ETHER SOLVENTS BAYER AKTIENGESELLSCHAFT (DE) 2021-04-15 WO claimed
EP-3772943-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING PROPYLENE CARBONATE Bayer Aktiengesellschaft (DE) 2021-02-17 EP claimed
EP-3646731-A1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-05-06 EP claimed
EP-3300602-B1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-03-25 EP claimed
WO-2019197635-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING PROPYLENE CARBONATE BAYER AKTIENGESELLSCHAFT (DE) 2019-10-17 WO claimed
EP-3010893-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2019-10-02 EP claimed
WO-2010078899-A2 METHOD FOR CONTROLLING RESISTANT ANIMAL PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-07-15 WO claimed
EP-2198709-A1 Method for treating resistant animal pests Bayer CropScience AG (DE) 2010-06-23 EP claimed
WO-2010060982-A2 PESTICIDE COMPOSITION COMPRISING A TETRAZOLYLOXIME DERIVATIVE AND A FUNGICIDE OR AN INSECTICIDE ACTIVE SUBSTANCE BAYER CROPSCIENCE SA (FR) 2010-06-03 WO claimed
US-20100130561-A1 CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS BAYER CROPSCIENCE AG (DE) 2010-05-27 US claimed
WO-2010003923-A1 PESTCIDAL ACTIVE MIXTURES COMPRISING ISOXAZOLINE COMPOUNDS I BASF SE (DE) 2010-01-14 WO claimed
WO-2009124707-A2 COMBINATIONS OF BIOLOGICAL CONTROL AGENTS AND INSECTICIDES OR FUNGICIDES BAYER CROPSCIENCE AG (DE) 2009-10-15 WO claimed
WO-2009118297-A2 PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS BASF SE (DE) 2009-10-01 WO claimed
EP-2090168-A1 Method for improving plant growth Bayer CropScience AG (DE) 2009-08-19 EP claimed
WO-2009090181-A2 PESTICIDE COMPOSITION COMPRISING A TETRAZOLYLOXIME DERIVATIVE AND A FUNGICIDE OR AN INSECTICIDE ACTIVE SUBSTANCE BAYER CROPSCIENCE SA (FR) 2009-07-23 WO claimed
EP-2044841-A1 Method for improving plant growth Bayer CropScience AG (DE) 2009-04-08 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230068010-A1 FORMULATION OF INSECTICIDAL MIXTURES COMPRISING GLYCOL ETHER SOLVENTS SGMS2, SGMS1, CYP51A1 CHRNA1 4238/4885CHRNB2 3758/4885CHRNA3 3294/4885
US-20100130561-A1 CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS AADAC, ATL3, ANTXR2 CHRNA1 4147/4885CHRNB2 3787/4885CHRNA3 3158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.