Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | GPX4 | P36969 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046644 | 0.85 | PDE7A (0.42) | ALDH1A1MAPK1NPSR1TSHRDUSP3 | |
| SCHEMBL12060227 | 0.84 | MAPT (0.44) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046648 | 0.82 | KCNK3 (0.48) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046655 | 0.82 | SLC5A1 (0.43) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046645 | 0.82 | KCNK3 (0.42) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL15850622 | 0.82 | CCNA2 (0.55) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL15850651 | 0.81 | CCNA2 (0.45) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046634 | 0.81 | CCNA2 (0.44) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046640 | 0.80 | ALDH1A1 (0.52) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 | |
| SCHEMBL12046650 | 0.80 | CCNA2 (0.46) | KCNK3ALDH1A1MAPK1NPSR1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028451-A1 | Dihydrobenzoindazoles | DHODH, BRDT, HSD17B11 | KCNK3 555/4885ALDH1A1 54/4885MAPK1 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.