Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 6/20 | 0.46 |
| ▸ | FDPS | P14324 | 5/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060358 | 0.94 | GGPS1 (0.48) | GGPS1FDPSPTPN5MMP13KDM4E | |
| SCHEMBL12048147 | 0.87 | GGPS1 (0.54) | GGPS1FDPSPTPN5ALDH1A1 | |
| SCHEMBL11952615 | 0.84 | GGPS1 (0.52) | GGPS1FDPSKDM4EALDH1A1 | |
| SCHEMBL12060525 | 0.83 | GGPS1 (0.38) | GGPS1FDPSPTPN5MMP13KDM4E | |
| SCHEMBL12048172 | 0.81 | FDPS (0.50) | GGPS1FDPS | |
| SCHEMBL12048125 | 0.79 | GGPS1 (0.59) | GGPS1FDPSPTPN5 | |
| SCHEMBL12048169 | 0.77 | GGPS1 (0.49) | GGPS1FDPS | |
| SCHEMBL12060351 | 0.77 | GGPS1 (0.56) | GGPS1FDPSKDM4EALDH1A1 | |
| SCHEMBL12048259 | 0.76 | GGPS1 (0.52) | GGPS1FDPSKDM4E | |
| SCHEMBL12048155 | 0.75 | FDPS (0.49) | GGPS1FDPSPTPN5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |