Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 13/20 | 0.49 |
| ▸ | GGPS1 | O95749 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060363 | 0.91 | FDPS (0.54) | FDPSGGPS1LMNAALDH1A1HTT | |
| SCHEMBL12048147 | 0.88 | GGPS1 (0.54) | FDPSGGPS1LMNAALDH1A1HTT | |
| SCHEMBL12048185 | 0.85 | GGPS1 (0.57) | FDPSGGPS1PTPN5 | |
| SCHEMBL12048156 | 0.81 | GGPS1 (0.47) | FDPSGGPS1 | |
| SCHEMBL12048125 | 0.78 | GGPS1 (0.59) | FDPSGGPS1PTPN5BTN3A1PDE3A | |
| SCHEMBL12048152 | 0.77 | GGPS1 (0.48) | FDPSGGPS1 | |
| SCHEMBL12048182 | 0.77 | FDPS (0.42) | FDPSGGPS1 | |
| SCHEMBL12048203 | 0.77 | FDPS (0.40) | FDPSGGPS1 | |
| SCHEMBL12048176 | 0.77 | CHKA (0.41) | FDPSGGPS1LMNAALDH1A1HTT | |
| SCHEMBL12048146 | 0.76 | GGPS1 (0.76) | FDPSGGPS1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |