Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 9/20 | 0.44 |
| ▸ | TUBB | P07437 | 9/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12050633 | 0.79 | CALCRL (0.50) | CALCRLNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL12050348 | 0.78 | CALCRL (0.49) | CALCRLCALCA | |
| SCHEMBL12050643 | 0.76 | CALCRL (0.47) | CALCRLCALCA | |
| SCHEMBL12050415 | 0.74 | CALCRL (0.61) | CALCRLKDM4EALDH1A1HPGDCALCA | |
| SCHEMBL12990901 | 0.74 | CALCA (0.47) | CALCRLNPC1RAB9AKDM4EMEN1 | |
| SCHEMBL12050642 | 0.73 | CALCRL (0.45) | CALCRLKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL12060842 | 0.73 | CALCRL (0.55) | CALCRLKDM4EKMT2ACALCA | |
| SCHEMBL4623517 | 0.72 | MEN1 (0.72) | NPC1RAB9AKDM4EMEN1ALDH1A1 | |
| SCHEMBL12050619 | 0.72 | CALCRL (0.54) | CALCRLALDH1A1CALCA | |
| SCHEMBL12050623 | 0.72 | CALCRL (0.47) | CALCRLCALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071770-B2 | Spirohydantoin aryl CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071770-B2 | Spirohydantoin aryl CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20090239870-A1 | Spirohydantoin Aryl Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-09-24 | — | — | US | disclosed |
| US-20090239870-A1 | Spirohydantoin Aryl Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-09-24 | — | — | US | disclosed |
| WO-2007061676-A2 | SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239870-A1 | Spirohydantoin Aryl Cgrp Receptor Antagonists | BDKRB1, BDKRB2, CALCRL | CALCRL 3/4885NPC1 706/4885RAB9A 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.