SCHEMBL4623517

SCHEMBL4623517

C(=Cc1nc2cc3nc(C=Cc4ccccc4)[nH]c3cc2[nH]1)c1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.72
▸ KMT2A Q03164 5/20 0.72
▸ RAB9A P51151 4/20 0.72
▸ NPC1 O15118 3/20 0.72
▸ KDM4E B2RXH2 3/20 0.72
▸ ALDH1A1 P00352 2/20 0.72
▸ PKM P14618 2/20 0.72
▸ HPGD P15428 2/20 0.72
▸ SMN1; SMN2 Q16637 2/20 0.72
▸ HSP90AA1 P07900 1/20 0.72
▸ TUBB4A P04350 9/20 0.57
▸ TUBB P07437 9/20 0.57
▸ TUBA3C P0DPH7 9/20 0.57
▸ TUBA1B P68363 9/20 0.57
▸ TUBA4A P68366 9/20 0.57
▸ TUBB4B P68371 9/20 0.57
▸ TUBB3 Q13509 9/20 0.57
▸ TUBB2A Q13885 9/20 0.57
▸ TUBB8 Q3ZCM7 9/20 0.57
▸ TUBA3E Q6PEY2 9/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29467927 0.87 NPC1 (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL29467918 0.87 RAB9A (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL28698968 0.87 NPC1 (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL6836616 0.87 KDM4E (0.75) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL28258355 0.87 NPC1 (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL28691230 0.87 RAB9A (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL29467917 0.87 NPC1 (0.64) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL6836889 0.87 KDM4E (0.75) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL537904 0.84 NPC1 (1.00) MEN1KMT2ARAB9ANPC1KDM4E
SCHEMBL537905 0.84 NPC1 (1.00) MEN1KMT2ARAB9ANPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1353642-B1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING AN AMPHIPHILIC COPOYLMER COMPRISING 2-ACRYLAMIDO-2-PROPANESULFONIC AND (METH)ACRYLATES OREAL (FR) 2008-05-07 — — EP claimed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 — — US claimed
US-7045120-B2 Photoprotective/cosmetic compositions comprising sulfonic/hydrophobic amphiphilic polymers L'OREAL (FR) 2006-05-16 — — US claimed
US-20040071641-A1 Photoprotective/cosmetic compositions comprising sulfonic/hydrophobic amphiphilic polymers SOCIETE L'OREAL S.A. (FR) 2004-04-15 — — US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 — — US claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 — — US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 — — US claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 — — EP disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 — — US disclosed
WO-2014010100-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2014-01-16 — — WO disclosed
WO-2014010099-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARING THE SAME L'OREAL (FR) 2014-01-16 — — WO disclosed
US-7416721-B2 Sunscreen compositions comprising insoluble organic UV-screening agents and hydroxyalkylurea compounds L'OREAL (FR) 2008-08-26 — — US disclosed
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 — — US disclosed
US-20050058612-A1 Use of amphiphilic copolymers to stabilize dispersions of insoluble organic compounds for screening out UV radiation, dispersions stabilized with these copolymers and cosmetic compositions containing them L'OREAL (FR) 2005-03-17 — — US disclosed
US-6818206-B2 CONTROLLING PARTICLE SIZES; TOPICAL APPLYING L'OREAL (FR) 2004-11-16 — — US disclosed
US-20040071641-A1 Photoprotective/cosmetic compositions comprising sulfonic/hydrophobic amphiphilic polymers SOCIETE L'OREAL S.A. (FR) 2004-04-15 — — US disclosed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 — — US disclosed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 — — US disclosed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 — — US disclosed
US-20030129151-A1 Use of amphiphilic copolymers to stabilize dispersions of insoluble organic compounds for screening out UVradiation, dispersions stabilized with these copolymers and cosmetic compositions containing them L'OREAL (FR) 2003-07-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030129151-A1 Use of amphiphilic copolymers to stabilize dispersions of insoluble organic compounds for screening out UVradiation, dispersions stabilized with these copolymers and cosmetic compositions containing them CUTA, HNRNPU, ERCC5 MEN1 3351/4885KMT2A 4704/4885RAB9A 2892/4885
US-20050058612-A1 Use of amphiphilic copolymers to stabilize dispersions of insoluble organic compounds for screening out UV radiation, dispersions stabilized with these copolymers and cosmetic compositions containing them CUTA, ERCC5, ERCC1 MEN1 3234/4885KMT2A 4523/4885RAB9A 3179/4885
US-20040071641-A1 Photoprotective/cosmetic compositions comprising sulfonic/hydrophobic amphiphilic polymers CUTA, DSG1, PCNA MEN1 1959/4885KMT2A 3069/4885RAB9A 4654/4885
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD MEN1 4027/4885KMT2A 3376/4885RAB9A 4067/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR MEN1 341/4885KMT2A 3148/4885RAB9A 1355/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 MEN1 3716/4885KMT2A 3626/4885RAB9A 4526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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