Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CNR2 | P34972 | 9/20 | 0.58 |
| ▸ | KIF11 | P52732 | 2/20 | 0.56 |
| ▸ | CNR1 | P21554 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057591 | 1.00 | ALDH1A1 (0.58) | ALDH1A1TSHRCNR2KIF11CNR1 | |
| SCHEMBL12057606 | 0.84 | PTPN1 (0.63) | ALDH1A1TSHRHPGDALOX15HSD17B10 | |
| SCHEMBL12057595 | 0.83 | PTPN1 (0.62) | ALDH1A1TSHRHPGDALOX15HSD17B10 | |
| SCHEMBL13631324 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TSHRCNR2HPGDALOX15 | |
| SCHEMBL12057605 | 0.79 | MAPT (0.74) | ALDH1A1TSHRCNR2CNR1HPGD | |
| SCHEMBL21597132 | 0.77 | FLT3 (0.67) | ALDH1A1TSHRCNR2KIF11CNR1 | |
| SCHEMBL16848805 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TSHRCNR2CNR1HPGD | |
| SCHEMBL21603653 | 0.76 | FLT3 (0.68) | ALDH1A1TSHRCNR2KIF11CNR1 | |
| SCHEMBL16210887 | 0.74 | KMT2A (0.74) | ALDH1A1CNR2KIF11CNR1HPGD | |
| SCHEMBL17018756 | 0.74 | ALDH1A1 (0.55) | ALDH1A1TSHRCNR2CNR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2583963-A1 | Proline analogs as ligands for cannabinoid receptors for the treatment of pain | Purdue Pharma L.P. (US) | 2013-04-24 | — | — | EP | disclosed |
| US-8084612-B2 | Proline analogs as ligands for cannabinoid receptors | PURDUE PHARMA L.P. (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084612-B2 | Proline analogs as ligands for cannabinoid receptors | PURDUE PHARMA L.P. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | PURDUE PHARMA L.P. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | PURDUE PHARMA L.P. (US) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2632/4885TSHR 1430/4885CNR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.