Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.62 |
| ▸ | PTPRC | P08575 | 1/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPRB | P23467 | 1/20 | 0.62 |
| ▸ | PTPRE | P23469 | 1/20 | 0.62 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.62 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057606 | 0.99 | PTPN1 (0.63) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL13631324 | 0.89 | ALDH1A1 (0.56) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL12057607 | 0.83 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1HPGDALOX15 | |
| SCHEMBL12057591 | 0.83 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1HPGDALOX15 | |
| SCHEMBL12057605 | 0.83 | MAPT (0.74) | ALDH1A1HPGDALOX15TSHRHSD17B10 | |
| SCHEMBL16848805 | 0.82 | ALDH1A1 (0.50) | GRIN2CMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3918254 | 0.80 | MEN1 (0.75) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL22435152 | 0.79 | PTPN1 (0.77) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL6247381 | 0.79 | ALDH1A1 (0.70) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL20541663 | 0.79 | ALDH1A1 (0.74) | PTPN1PTPRCPTPN2PTPRBPTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | ELI LILLY AND COMPANY (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | ELI LILLY AND COMPANY | 2020-01-30 | — | — | US | disclosed |
| US-9604977-B2 | Bicyclic thiophenylamide compounds | HOFFMAN-LA ROCHE INC. (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2861574-B1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-8084612-B2 | Proline analogs as ligands for cannabinoid receptors | PURDUE PHARMA L.P. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | PURDUE PHARMA L.P. (US) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | SLC34A2, ALPI, SLC34A1 | PTPN1 588/4885PTPRC 493/4885PTPN2 284/4885 |
| US-20090291947-A1 | PROLINE ANALOGS AS LIGANDS FOR CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | PTPN1 985/4885PTPRC 656/4885PTPN2 1289/4885 |
| US-20150175594-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, BICRA | PTPN1 3655/4885PTPRC 2771/4885PTPN2 3794/4885 |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | SLC34A2, ALPI, SLC34A1 | PTPN1 588/4885PTPRC 493/4885PTPN2 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.