Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748653 | 0.85 | KCNK3 (0.69) | KMT2AMEN1RXFP1NPC1RAB9A | |
| SCHEMBL3241551 | 0.83 | KMT2A (0.69) | KMT2AMEN1NPC1RAB9AKCNK3 | |
| SCHEMBL29502995 | 0.83 | KMT2A (0.69) | KMT2AMEN1NPC1RAB9AKCNK3 | |
| SCHEMBL19070454 | 0.82 | MAPT (0.59) | KMT2AMEN1RXFP1NPC1RAB9A | |
| SCHEMBL3101556 | 0.82 | RAB9A (0.59) | KMT2AMEN1RXFP1NPC1RAB9A | |
| SCHEMBL12192807 | 0.82 | KCNK3 (0.64) | RXFP1NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL5897054 | 0.80 | MAPK14 (0.65) | RAB9AKCNK3KDM4EMAPTMAPK14 | |
| SCHEMBL374471 | 0.79 | PTGS1 (0.70) | KMT2AMEN1RAB9AKCNK3KCNK9 | |
| SCHEMBL10092868 | 0.79 | CSF1R (0.55) | KMT2AMEN1RAB9AKCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL5004557 | 0.78 | PTGS1 (0.68) | KMT2AMEN1RAB9AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147764-A1 | THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS | N.V. ORGANON (NL) | 2011-12-01 | — | — | WO | disclosed |