Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1208564 | 0.81 | SMN1; SMN2 (0.54) | HPGDALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL27835703 | 0.75 | DDX3X (0.47) | HPGDALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL1207103 | 0.75 | DDX3X (0.50) | HPGDALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL1207814 | 0.75 | AR (0.58) | GAANPC1RAB9AMAPT | |
| SCHEMBL1206548 | 0.73 | ALDH1A1 (0.36) | HPGDALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL1207630 | 0.72 | DDX3X (0.50) | HPGDALDH1A1ALOX15HSD17B10KDM4E | |
| (2-Aminophenyl)(Morpholino)Methanone SCHEMBL30988542 | 0.70 | GAA (0.62) | HPGDALDH1A1HSD17B10KDM4EGAA | |
| (2-Aminophenyl)(Morpholino)Methanone SCHEMBL11446442 | 0.70 | GAA (0.62) | HPGDALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL10578647 | 0.69 | HPGD (0.51) | HPGDALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL5007920 | 0.68 | HPGD (0.51) | HTR2CHPGDALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| EP-2215066-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009058348-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009058348-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2C 4482/4885CNR1 2601/4885HPGD 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.