Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978283 | 0.84 | KDM4E (0.38) | KDM4ELMNACTSLALOX15NPC1 | |
| SCHEMBL17765162 | 0.82 | DGAT1 (0.34) | — | |
| SCHEMBL18982796 | 0.77 | HSD11B1 (0.38) | KDM4ESLC22A12 | |
| SCHEMBL17765122 | 0.77 | KCNJ11 (0.34) | LMNACTSLSLC22A12SMN1; SMN2 | |
| SCHEMBL18730405 | 0.74 | NPC1 (0.39) | KDM4ELMNAALOX15SLC22A12NPC1 | |
| SCHEMBL18730380 | 0.72 | KDM4E (0.39) | KDM4ESMN1; SMN2 | |
| SCHEMBL18498462 | 0.70 | KDM4E (0.42) | KDM4ENAPRTHCAR2LMNASLC22A12 | |
| SCHEMBL28511183 | 0.70 | KDM4E (0.42) | KDM4ENAPRTHCAR2LMNASLC22A12 | |
| SCHEMBL11249250 | 0.70 | KDM4E (0.39) | KDM4ENAPRTHCAR2LMNACTSL | |
| SCHEMBL17765252 | 0.69 | AGBL2 (0.36) | KDM4ELMNASLC22A12NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149921-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-01 | — | — | WO | disclosed |