Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | BLM | P54132 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | CASP7 | P55210 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067012 | 0.74 | ADORA2A (0.49) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL30180856 | 0.72 | KDM4E (0.52) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL12067032 | 0.72 | NT5E (0.38) | ADORA2AADORA1MAPT | |
| SCHEMBL12069748 | 0.72 | POLB (0.39) | ADORA2AADORA1POLBMAPTMEN1 | |
| SCHEMBL12067035 | 0.72 | PDE10A (0.41) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL12067030 | 0.70 | ADORA2A (0.41) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL28465630 | 0.69 | TDP1 (0.54) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL4459534 | 0.67 | ADORA2A (1.00) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL2114343 | 0.67 | MAPT (1.00) | ADORA2AADORA1POLBMAPTALDH1A1 | |
| SCHEMBL18583293 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083388-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2016-03-24 | — | — | US | disclosed |
| US-9139592-B2 | Modulators of Nrf2 and uses thereof | TRT PHARMA INC. (CA) | 2015-09-22 | — | — | US | disclosed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| WO-2011156889-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | ADORA2A 4278/4885ADORA1 4677/4885POLB 3935/4885 |
| US-20160083388-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | ADORA2A 4278/4885ADORA1 4677/4885POLB 3935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.