Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 10/20 | 0.33 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852948 | 1.00 | F2 (0.33) | F2PRSS1MERTKAXLTYRO3 | |
| SCHEMBL14852901 | 0.87 | CHRM3 (0.33) | F2PRSS1MERTKAXLTYRO3 | |
| SCHEMBL12067752 | 0.87 | CHRM3 (0.33) | F2PRSS1MERTKAXLTYRO3 | |
| SCHEMBL17086375 | 0.86 | ESR1 (0.33) | RIPK1CHRM3 | |
| SCHEMBL14948679 | 0.86 | AXL (0.33) | MERTKAXLTYRO3RIPK1CHRM3 | |
| SCHEMBL13631329 | 0.86 | ESR1 (0.33) | RIPK1CHRM3 | |
| SCHEMBL10208829 | 0.84 | OPRK1 (0.36) | KDM1AMAOB | |
| SCHEMBL16072108 | 0.83 | CHRM3 (0.33) | HTR1ADRD3CHRM3KDM1AMAOB | |
| SCHEMBL13631305 | 0.82 | DGAT1 (0.36) | — | |
| SCHEMBL13631314 | 0.82 | RIPK1 (0.30) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011157397-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-12-22 | — | — | WO | disclosed |
| EP-2397482-A1 | Heteroaryl imidazolone derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-12-21 | — | — | EP | disclosed |