SCHEMBL12068858

CCOC(=O)[C@H](C)NP(=O)(N[C@@H](C)C(=O)OCC)OC[C@H]1O[C@@H](c2ccc3c(N)ncnn23)[C@](C)(O)[C@@H]1OC(=O)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	POLRMT	O00411	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12066945	0.93	CYP3A4 (0.33)	POLRMT
SCHEMBL12066946	0.93	CYP3A4 (0.33)	POLRMT
SCHEMBL12067528	0.90	CYP3A4 (0.40)	—
SCHEMBL12067496	0.87	CYP3A4 (0.33)	POLRMT
SCHEMBL12067502	0.86	CYP3A4 (0.32)	POLRMT
SCHEMBL12066944	0.84	CYP3A4 (0.47)	POLRMT
SCHEMBL12066943	0.84	CYP3A4 (0.47)	POLRMT
SCHEMBL12066935	0.83	POLRMT (0.34)	POLRMT
SCHEMBL12068827	0.82	CYP3A4 (0.33)	POLRMT
SCHEMBL10142368	0.82	TMPRSS2 (0.31)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011150288-A1	1'-SUBSTITUTED-CARBA-NUCLEOSIDE PRODRUGS FOR ANTIVIRAL TREATMENT	GILEAD SCIENCES, INC. (US)	2011-12-01	—	—	WO	disclosed