SCHEMBL120720

SCHEMBL120720

Nc1ncnc2c1ncn2-n1cnc2cncnc21

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 12/20 0.49
▸ ADORA1 P30542 8/20 0.49
▸ PI4KA P42356 11/20 0.46
▸ PI4K2B Q8TCG2 11/20 0.46
▸ PI4K2A Q9BTU6 11/20 0.46
▸ PI4KB Q9UBF8 11/20 0.46
▸ ADORA2B P29275 4/20 0.45
▸ EGFR P00533 2/20 0.43
▸ ADORA3 P0DMS8 2/20 0.42
▸ SRC P12931 1/20 0.40
▸ KDR P35968 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL580610 0.84 ADORA2A (0.64) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL6036330 0.83 CDK1 (0.44) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL28413958 0.82 ADORA2A (0.62) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL2120550 0.82 FDPS (0.45) EGFR
SCHEMBL3506547 0.81 ADORA2A (0.46) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL28553166 0.81 PI4KA (0.37) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL28410735 0.81 ADORA2A (0.60) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL731404 0.81 CYP2C9 (0.36) ADORA2AADORA1
SCHEMBL1820741 0.81 FDPS (0.35) —
SCHEMBL6959953 0.81 FDPS (0.38) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 433 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115666593-A Therapeutic agent for epithelial cancer 国立大学法人大阪大学 2023-01-31 — — CN claimed
US-6531581-B1 When incorporated into hairpin oligonucleotides these quench the fluorescence of fluorophores linked to the 5'-terminus of the oligonucleotide SEROLOGICALS, INC. 2003-03-11 — — US claimed
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNAimmune, Inc. (US) 2024-07-11 — — US disclosed
CN-118302181-A Multigang TP53 and PAN-RAS mRNA cancer vaccine 达冕生物有限公司 2024-07-05 — — CN disclosed
EP-4388017-A1 COMPOSITIONS AND METHODS FOR ANTI-VIRUS CHIMERIC ANTIGEN RECEPTOR Rudd, Christopher E. (CA) 2024-06-26 — — EP disclosed
EP-4384214-A2 COMPOSITION AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION Rnaimmune, Inc. (US) 2024-06-19 — — EP disclosed
US-11999995-B2 Methylome profiling in animals and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-04 — — US disclosed
CN-118119930-A Compositions and methods for mRNA vaccines against novel coronavirus infection 达冕生物有限公司 2024-05-31 — — CN disclosed
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-16 — — US disclosed
WO-2024097259-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-10 — — WO disclosed
WO-2024097894-A1 COMPOSITIONS AND METHODS OF RIBONUCLEIC ACID VACCINES ENCODING NYE-SO-1 RNAimmune, Inc. (US) 2024-05-10 — — WO disclosed
EP-0427799-A1 METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE. GENSIA PHARMA (US) 1991-05-22 — — EP disclosed
US-5008251-A Method of treating autism THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1991-04-16 — — US disclosed
WO-1991004032-A1 METHODS OF TREATING NEURODEGENERATIVE CONDITIONS GENSIA PHARMACEUTICALS, INC. (US) 1991-04-04 — — WO disclosed
WO-1990009163-A2 METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE GENSIA PHARMACEUTICALS, INC. (US) 1990-08-23 — — WO disclosed
US-4912092-A Prevent tissue damage; administering purine nucleoside THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1990-03-27 — — US disclosed
WO-1989000854-A1 METHODS FOR INCREASING EXTRACELLULAR ADENOSINE AND FOR STABILIZING MAST CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-02-09 — — WO disclosed
EP-0301900-A2 L'utilisation de riboside ou ribotide de l'AICA pour la fabrication d'un médicament contre la crise cardiaque ou l'infarctus du myocarde aux patients souffrant d'athérosclerosis. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-02-01 — — EP disclosed
EP-0270885-A1 Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids Bristol-Myers Squibb Company (US) 1988-06-15 — — EP disclosed
US-4713328-A DIAGNOSIS OF INFECTION USING BETA-LACTAMASE RAPIDEX LIMITED, 8402 THORNDEN TERRACE, BETHESDA, MD. 20034 A CORP. OF 1987-12-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RBM22, RNGTT, RBM25 ADORA2A 2677/4885ADORA1 3667/4885PI4KA 4029/4885
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNGTT, SARS1, ACE2 ADORA2A 3869/4885ADORA1 4244/4885PI4KA 1948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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