Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.65 |
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.65 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664850 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| SCHEMBL6664851 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Dihydro-Obliquin SCHEMBL12062091 | 0.79 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| SCHEMBL6843275 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Ayapin SCHEMBL6694210 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Ayapin SCHEMBL30171405 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Obliquin SCHEMBL12062102 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Obliquin SCHEMBL29534204 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| Obliquin SCHEMBL2255488 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10ACHE | |
| SCHEMBL28994323 | 0.71 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220545-A1 | COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | NEW YORK UNIVERSITY | 2012-08-30 | — | — | US | disclosed |
| WO-2011094016-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING | NEW YORK UNIVERSITY (US) | 2011-08-04 | — | — | WO | disclosed |
| US-20110190229-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING | NEW YORK UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220545-A1 | COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF | TYR, MC1R, MITF | KDM4E 79/4885ALDH1A1 246/4885HPGD 2055/4885 |
| US-20110190229-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING | TYR, MC1R, MITF | KDM4E 274/4885ALDH1A1 397/4885HPGD 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.