Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.62 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207953 | 0.90 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1208888 | 0.89 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1208157 | 0.88 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1210357 | 0.88 | NOD1 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1207597 | 0.88 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1209273 | 0.87 | TGFBR1 (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1207356 | 0.87 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1207657 | 0.86 | ALDH1A1 (0.60) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1209792 | 0.86 | TGFBR1 (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1207667 | 0.86 | ALDH1A1 (0.65) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | NYCOMED GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | BAX, BCL2, BAD | ALDH1A1 316/4885NPC1 4410/4885RAB9A 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.