SCHEMBL1208092

SCHEMBL1208092

O=[N+]([O-])c1ccc2c(c1)Sc1cc([N+](=O)[O-])ccc1N2

nearest known ligand 0.84

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SNCA P37840 10/20 0.84
▸ NOX1 Q9Y5S8 1/20 0.68
▸ CAPN9 O14815 1/20 0.50
▸ CASP3 P42574 1/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ NPC1 O15118 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ CYP3A4 P08684 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ SIRT2 Q8IXJ6 1/20 0.44
▸ LMNA P02545 1/20 0.43
▸ TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29625234 1.00 SNCA (0.84) SNCANOX1CAPN9CASP3MEN1
SCHEMBL29214094 0.93 SNCA (0.79) SNCANOX1CAPN9CASP3MEN1
SCHEMBL30867073 0.93 SNCA (0.79) SNCANOX1CAPN9CASP3MEN1
SCHEMBL14571431 0.92 SNCA (0.72) SNCANOX1CAPN9CASP3MEN1
Dimethyl Sulfoxide SCHEMBL18398818 0.92 SNCA (0.72) SNCANOX1CAPN9CASP3MEN1
SCHEMBL30769632 0.92 SNCA (1.00) SNCANOX1MEN1KMT2ANPC1
SCHEMBL239724 0.92 SNCA (1.00) SNCANOX1MEN1KMT2ANPC1
SCHEMBL26017582 0.90 SNCA (0.70) SNCANOX1CAPN9CASP3MEN1
SCHEMBL13210525 0.90 SNCA (0.70) SNCANOX1CAPN9CASP3MEN1
SCHEMBL8226190 0.87 SNCA (0.67) SNCANOX1CAPN9CASP3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117447421-A Synthesis method of 3, 7-bis- (dimethylamino) -phenothiazine 上海沃凯生物技术有限公司 2024-01-26 — — CN claimed
US-10700295-B2 Metal complexes UEA ENTERPRISES LIMITED (GB) 2020-06-30 — — US claimed
CN-109337681-B Preparation method and application of sulfur-nitrogen co-doped carbon quantum dot 南京工业大学 2020-05-08 — — CN claimed
US-20190131549-A1 METAL COMPLEXES UEA ENTERPRISES LIMITED (GB) 2019-05-02 — — US claimed
CN-104119294-B The preparation method of 3,7- diaminostilbene 0H- phenothiazine compounds 维斯塔实验室有限公司 2018-10-30 — — CN claimed
EP-3350189-A1 METAL COMPLEXES UEA Enterprises Limited (GB) 2018-07-25 — — EP claimed
WO-2017046572-A1 METAL COMPLEXES UNIVERSITY OF EAST ANGLIA (GB) 2017-03-23 — — WO claimed
US-9382220-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2016-07-05 — — US claimed
US-9174954-B2 3,7-diamino-10H-phenothiazine salts and their use WISTA LABORATORIES LTD. (SG) 2015-11-03 — — US claimed
US-20140221359-A1 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE Wis Ta Laboratories Ltd. (SG) 2014-08-07 — — US claimed
US-20130317012-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. (SG) 2013-11-28 — — US claimed
US-20110294795-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS WISTA LABORATORIES LTD. 2011-12-01 — — US claimed
US-7956183-B2 Methods of synthesis and/or purification of diaminophenothiazinium compounds WISTA LABORATORIES LTD. (SG) 2011-06-07 — — US claimed
US-20070129543-A1 PROCESSES FOR PREPARING NOVEL METHYLENE BLUE DERIVATIVE VERFICATION TECHNOLOGIES, INC. (US) 2007-06-07 — — US claimed
EP-1709020-A2 PROCESSES FOR PREPARING NOVEL METHYLENE BLUE DERIVATIVE Verification Technologies, Inc (US) 2006-10-11 — — EP claimed
WO-2005049561-A2 PROCESSES FOR PREPARING NOVEL METHYLENE BLUE DERIVATIVE VERIFICATION TECHNOLOGIES, INC. (US) 2005-06-02 — — WO claimed
US-20050107607-A1 Processes for preparing novel methylene blue derivative VERIFICATION TECHNOLOGIES, INC. 2005-05-19 — — US claimed
EP-4745659-A1 REFLECTING DEVICE, MANUFACTURING METHOD FOR REFLECTING DEVICE, AND VEHICLE BYD Company Limited (CN) 2026-05-20 — — EP disclosed
US-7176308-B2 Processes for preparing novel methylene blue derivative VERIFICATION TECHNOLOGIES, INC. (US) 2007-02-13 — — US disclosed
US-4500687-A GRAFT POLYMERIZING AN EPOXY MONOMER AND AN ADDITION POLYMERIZABLE MONOMER THE DOW CHEMICAL COMPANY (US) 1985-02-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190131549-A1 METAL COMPLEXES AP1M1, AP2M1, APOL1 SNCA 1654/4885NOX1 62/4885CAPN9 4173/4885
US-20140221359-A1 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE PSEN1, PSEN2, APP SNCA 517/4885NOX1 182/4885CAPN9 126/4885
US-10700295-B2 Metal complexes AP1M1, AP2M1, APOL1 SNCA 1654/4885NOX1 62/4885CAPN9 4173/4885
US-20070129543-A1 PROCESSES FOR PREPARING NOVEL METHYLENE BLUE DERIVATIVE MB, HMBS, KIT SNCA 266/4885NOX1 3596/4885CAPN9 1355/4885
US-20130317012-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MAPT, TPMT, UROD SNCA 227/4885NOX1 4259/4885CAPN9 1673/4885
US-20050107607-A1 Processes for preparing novel methylene blue derivative MB, HMBS, KIT SNCA 266/4885NOX1 3596/4885CAPN9 1355/4885
US-20110294795-A1 METHODS OF SYNTHESIS AND/OR PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS MMAB, MB, ABCB7 SNCA 1425/4885NOX1 3149/4885CAPN9 4829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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