Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081708 | 0.92 | SMN1; SMN2 (0.38) | LOXL2GPR84SMN1; SMN2KDM4EPOLB | |
| SCHEMBL12081769 | 0.89 | RXRA (0.44) | RXRARXRBGPR84POLBALDH1A1 | |
| SCHEMBL9853386 | 0.80 | TAAR1 (0.42) | RXRARXRBLOXL2SMN1; SMN2ALDH1A1 | |
| SCHEMBL9973082 | 0.80 | TAAR1 (0.42) | RXRARXRBLOXL2SMN1; SMN2ALDH1A1 | |
| SCHEMBL26559062 | 0.76 | RXRA (0.55) | RXRARXRBLOXL2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8105331 | 0.76 | NOS1 (0.53) | LOXL2SMN1; SMN2KDM4EALDH1A1NOS1 | |
| SCHEMBL27907919 | 0.74 | SMN1; SMN2 (0.37) | LOXL2SMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL11079658 | 0.74 | KDM4E (0.52) | LOXL2SMN1; SMN2KDM4EPOLBNOS1 | |
| SCHEMBL10666038 | 0.74 | ABAT (0.48) | RXRARXRBSMN1; SMN2KDM4EPOLB | |
| SCHEMBL27669043 | 0.74 | LOXL2 (0.37) | RXRARXRBLOXL2NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016946-A1 | DRUG-LOADED MACROMOLECULE AND PREPARATION METHOD THEREFOR | SHANGHAI SHENGDI PHARMACEUTICAL CO., LTD. (CN) | 2024-01-18 | — | — | US | disclosed |
| US-8420067-B2 | Targeted polylysine dendrimer therapeutic agent | STARPHARMA PTY LTD (AU) | 2013-04-16 | — | — | US | disclosed |
| US-8258259-B2 | Macromolecular compounds having controlled stoichiometry | STARPHARMA PTY LIMITED (AU) | 2012-09-04 | — | — | US | disclosed |
| US-20100292148-A1 | TARGETED POLYLYSINE DENDRIMER THERAPEUTIC AGENT | STARPHARMA PTY LTD. (AU) | 2010-11-18 | — | — | US | disclosed |
| US-20100278750-A1 | POLYLYSINE DENDRIMER CONTRAST AGENT | STARPHARMA PTY LTD | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278750-A1 | POLYLYSINE DENDRIMER CONTRAST AGENT | PARG, PARN, TLR3 | RXRA 4737/4885RXRB 4787/4885LOXL2 655/4885 |
| US-20240016946-A1 | DRUG-LOADED MACROMOLECULE AND PREPARATION METHOD THEREFOR | MRPL38, MRPS27, MRPS18A | RXRA 3547/4885RXRB 3754/4885LOXL2 1436/4885 |
| US-20100292148-A1 | TARGETED POLYLYSINE DENDRIMER THERAPEUTIC AGENT | CLTA, PARG, FLT3 | RXRA 4791/4885RXRB 4831/4885LOXL2 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.