Trifluperidol

Trifluperidol

SCHEMBL120862

O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 1.00
CYP2D6 P10635 3/20 1.00
ABCB11 O95342 2/20 1.00
TSHR P16473 2/20 1.00
THPO P40225 2/20 1.00
MTOR P42345 2/20 1.00
EBP Q15125 2/20 1.00
SIGMAR1 Q99720 2/20 1.00
TP53 P04637 1/20 1.00
PKM P14618 1/20 1.00
MAPK1 P28482 1/20 1.00
PMP22 Q01453 2/20 0.98
KDM4E B2RXH2 1/20 0.98
SMN1; SMN2 Q16637 1/20 0.98
DRD2 P14416 13/20 0.77
CYP1A2 P05177 2/20 0.64
HTR1A P08908 2/20 0.64
ADRA2A P08913 2/20 0.64
CHRM1 P11229 2/20 0.64
ADRA2B P18089 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluperidol SCHEMBL29710906 1.00 CYP3A4 (1.00) CYP3A4CYP2D6ABCB11TSHRTHPO
Trifluperidol SCHEMBL316725 0.99 PMP22 (1.00) CYP3A4CYP2D6ABCB11TSHRTHPO
Trifluperidol SCHEMBL14973483 0.99 PMP22 (1.00) CYP3A4CYP2D6ABCB11TSHRTHPO
Trifluperidol SCHEMBL28086762 0.94 ABCB11 (0.88) CYP3A4CYP2D6ABCB11TSHRTHPO
Trifluperidol SCHEMBL13724801 0.93 CYP3A4 (0.86) CYP3A4CYP2D6ABCB11TSHRTHPO
SCHEMBL9053345 0.92 ABCB11 (0.85) CYP3A4CYP2D6ABCB11TSHRTHPO
Trifluperidol SCHEMBL5490310 0.91 CYP3A4 (0.83) CYP3A4CYP2D6ABCB11TSHRTHPO
SCHEMBL9053658 0.88 DRD2 (0.82) CYP3A4CYP2D6ABCB11TSHRTHPO
SCHEMBL11373842 0.88 ABCB11 (0.78) CYP3A4CYP2D6ABCB11TSHRTHPO
SCHEMBL9050645 0.87 DRD2 (1.00) CYP3A4CYP2D6ABCB11TSHRTHPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2846 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724062-A2 COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA EmpathBio, Inc. (US) 2026-04-15 EP claimed
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 EP claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 US claimed
CN-113563246-B Substituted aza five-membered ring derivative and application thereof in medicines 广东东阳光药业股份有限公司 2025-01-17 CN claimed
CN-113563244-B Substituted aza five-membered ring compound and application thereof in medicine 广东东阳光药业股份有限公司 2025-01-10 CN claimed
US-20240408054-A1 COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA EMPATHBIO, INC. 2024-12-12 US claimed
WO-2024254505-A2 COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA ATAI Life Sciences AG (DE) 2024-12-12 WO claimed
CN-113563245-B Substituted pyrrolidines and their use in medicine 广东东阳光药业股份有限公司 2024-10-15 CN claimed
US-12102640-B2 Use of dopamine and serotonin receptor antagonists for treatment in a subject with retinal degeneration UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) 2024-10-01 US claimed
EP-4398893-A1 IBOGAINE COMBINATION TREATMENT atai Life Sciences AG (DE) 2024-07-17 EP claimed
WO-1995032981-A1 NOVEL GLYCOSIDE COMPOUNDS AND PRODUCTION AND USE THEREOF HARRIER, INC. (US) 1995-12-07 WO claimed
EP-0441333-B1 Pharmaceutical composition SHOWA PHARM CHEM IND (JP) 1994-05-11 EP claimed
US-5118508-A Butyrophenone compound; vehicle of polyvinyl acetal diethylaminoacetate and polyvinyl pyrrolidone; cataplasm, treatment of vomitting and schizophreneia SHOWA YAKUHIN KAKO CO., LTD. (JP) 1992-06-02 US claimed
EP-0441333-A1 Pharmaceutical composition SHOWA YAKUHIN KAKO CO., LTD. (JP) 1991-08-14 EP claimed
US-4938758-A Anti-pathogenic blood collection system and method AL SIOUFI HABIB (US) 1990-07-03 US claimed
EP-0263873-A4 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD. AL-SIOUFI HABIB 1989-07-11 EP claimed
EP-0263873-A1 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD AL-SIOUFI, Habib (US) 1988-04-20 EP claimed
WO-1987006119-A1 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD AL SIOUFI HABIB 1987-10-22 WO claimed
US-4565821-A 4-PIPERADINO-4*-FLUOROBUTYROPHENONES THE TEXAS A&M UNIVERSITY SYSTEM (US) 1986-01-21 US claimed
US-3947579-A HALOGENATED AMINO ACID NELSON RESEARCH & DEVELOPMENT COMPANY (US) 1976-03-30 US claimed