Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.85 |
| ▸ | TP53 | P04637 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.85 |
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | THPO | P40225 | 1/20 | 0.85 |
| ▸ | MTOR | P42345 | 1/20 | 0.85 |
| ▸ | EBP | Q15125 | 1/20 | 0.85 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | DRD2 | P14416 | 9/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.69 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluperidol SCHEMBL29710906 | 0.92 | CYP3A4 (1.00) | ABCB11TP53CYP3A4CYP2D6PKM | |
| Trifluperidol SCHEMBL120862 | 0.92 | CYP3A4 (1.00) | ABCB11TP53CYP3A4CYP2D6PKM | |
| Trifluperidol SCHEMBL14973483 | 0.91 | PMP22 (1.00) | ABCB11TP53CYP3A4CYP2D6PKM | |
| Trifluperidol SCHEMBL316725 | 0.91 | PMP22 (1.00) | ABCB11TP53CYP3A4CYP2D6PKM | |
| SCHEMBL9052747 | 0.88 | DRD2 (0.82) | ABCB11TP53CYP3A4CYP2D6PKM | |
| Trifluperidol SCHEMBL28086762 | 0.86 | ABCB11 (0.88) | ABCB11TP53CYP3A4CYP2D6PKM | |
| SCHEMBL9055953 | 0.86 | DRD2 (0.78) | ABCB11TP53CYP3A4CYP2D6PKM | |
| SCHEMBL8986029 | 0.85 | DRD2 (1.00) | ABCB11CYP3A4CYP2D6TSHRTHPO | |
| Trifluperidol SCHEMBL13724801 | 0.85 | CYP3A4 (0.86) | ABCB11TP53CYP3A4CYP2D6PKM | |
| SCHEMBL9053073 | 0.84 | DRD2 (0.80) | ABCB11TP53CYP3A4CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996002250-A1 | HALOPERIDOL ANALOGS AND THE USE THEREOF | ACEA PHARMACEUTICALS INC. (US) | 1996-02-01 | — | — | WO | disclosed |
| US-4065565-A | Acylhydrazones and anti-psychotic compositions thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-27 | — | — | US | disclosed |