Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12928360 | 0.81 | TSHR (0.54) | KMT2ALMNATP53GRM5HDAC1 | |
| SCHEMBL21891696 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL12086294 | 0.81 | GRM5 (0.47) | CES2CES1GRM5RIPK1 | |
| SCHEMBL9557605 | 0.80 | MEN1 (0.43) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL12084858 | 0.79 | CES2 (0.52) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL254969 | 0.79 | ALDH1A1 (0.56) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL14134492 | 0.78 | MEN1 (0.58) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL255338 | 0.77 | KMT2A (0.54) | MEN1KMT2ALMNARAB9ANPC1 | |
| SCHEMBL21891718 | 0.76 | BCAT2 (0.49) | MEN1KMT2ATP53HTT | |
| SCHEMBL8173976 | 0.76 | MEN1 (0.49) | MEN1KMT2ARAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258148-B2 | Spiroindoline modulators of muscarinic receptors | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-09-04 | — | — | US | disclosed |