SCHEMBL12091007

SCHEMBL12091007

CC(=O)c1cncc(Cl)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 2/20 0.46
CDK2 P24941 2/20 0.41
CTSA P10619 1/20 0.40
S1PR3 Q99500 1/20 0.39
KDM1A O60341 2/20 0.33
ALDH1A1 P00352 2/20 0.33
USP7 Q93009 2/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
HCAR2 Q8TDS4 1/20 0.32
SIRT6 Q8N6T7 1/20 0.32
SCN2A Q99250 1/20 0.32
SCN10A Q9Y5Y9 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30354632 1.00 GRM5 (0.46) GRM5CDK2CTSAS1PR3KDM1A
SCHEMBL16310786 0.84 ALDH1A1 (0.39) GRM5KDM1AALDH1A1USP7HCAR2
SCHEMBL27858703 0.82 GRM5 (0.49) GRM5CDK2CTSAS1PR3ALDH1A1
SCHEMBL376147 0.80 GRM5 (0.47) GRM5CDK2CTSAS1PR3ALDH1A1
SCHEMBL29913176 0.80 GRM5 (0.47) GRM5CDK2CTSAS1PR3ALDH1A1
SCHEMBL376231 0.80 GRM5 (0.47) GRM5CDK2CTSAS1PR3ALDH1A1
SCHEMBL21935434 0.78 USP7 (0.33) KDM1AALDH1A1USP7PDE4APDE4B
SCHEMBL20780106 0.78 CDK2 (0.41) GRM5CDK2CTSAS1PR3ALDH1A1
SCHEMBL741061 0.78 SIRT6 (0.50) GRM5CDK2CTSAS1PR3SIRT6
SCHEMBL31555012 0.78 SIRT6 (0.50) GRM5CDK2CTSAS1PR3SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545689-B2 Macrocyclic LRRK2 kinase inhibitors ONCODESIGN PRECISION MEDICINE (FR) 2026-02-10 US disclosed
EP-4146658-B1 NEW MACROCYCLIC LRRK2 KINASE INHIBITORS ONCODESIGN PREC MEDICINE OPM (FR) 2025-10-29 EP disclosed
US-12433895-B2 Therapeutically active compounds and their methods of use SERVIER PHARMACEUTICALS LLC (US) 2025-10-07 US disclosed
US-20250304577-A1 TYK2 INHIBITORS BIOGEN MA INC. 2025-10-02 US disclosed
US-12145924-B2 Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds ELI LILLY AND COMPANY (US) 2024-11-19 US disclosed
US-20240335448-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE PHARMARESROUCES (SHANGHAI) CO., LTD. (CN) 2024-10-10 US disclosed
US-11844758-B2 Therapeutically active compounds and their methods of use SERVIER PHARMACEUTICALS LLC (US) 2023-12-19 US disclosed
WO-2023220046-A1 TYK2 INHIBITORS BIOGEN MA INC. (US) 2023-11-16 WO disclosed
US-20230357269-A1 NEW MACROCYCLIC LRRK2 KINASE INHIBITORS ONCODESIGN PRECISION MEDICINE (FR) 2023-11-09 US disclosed
EP-3679032-B1 LYSOPHOSPHATIDIC ACID RECEPTOR 1 (LPAR1) INHIBITOR COMPOUNDS LILLY CO ELI (US) 2023-10-04 EP disclosed
US-20160220572-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2016-08-04 US disclosed
US-20160220572-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2016-08-04 US disclosed
US-20160220572-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2016-08-04 US disclosed
EP-3019483-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE Agios Pharmaceuticals, Inc. (US) 2016-05-18 EP disclosed
WO-2015003640-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC. (US) 2015-01-15 WO disclosed
US-8367831-B2 Heterocyclic compound or salt thereof and intermediate thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-02-05 US disclosed
US-20120226035-A1 NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-09-06 US disclosed
US-20110313156-A1 HETEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-12-22 US disclosed
US-20110177612-A1 Human G Protein-Coupled Receptors and Modulators Thereof for the Treatment of Metabolic-Related Disorders ARENA PHARMACEUTICALS, INC. 2011-07-21 US disclosed
US-20080139628-A1 Compositions For Treating Flushing And Lipid-Associated Disorders Comprising Niacin Receptor Partial Agonists ARENA PHARMACEUTICALS, INC. (US) 2008-06-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12433895-B2 Therapeutically active compounds and their methods of use MCL1, TP53, BRDT GRM5 2427/4885CDK2 1060/4885CTSA 317/4885
US-12545689-B2 Macrocyclic LRRK2 kinase inhibitors LRRK2, SNCA, ROS1 GRM5 2435/4885CDK2 233/4885CTSA 1733/4885
US-20250304577-A1 TYK2 INHIBITORS TYK2, JAK2, JAK1 GRM5 2770/4885CDK2 220/4885CTSA 3046/4885
US-20110313156-A1 HETEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS PDK2, PDK4, CCNH GRM5 4854/4885CDK2 142/4885CTSA 270/4885
US-11844758-B2 Therapeutically active compounds and their methods of use MCL1, TP53, BRDT GRM5 2427/4885CDK2 1060/4885CTSA 317/4885
US-20080139628-A1 Compositions For Treating Flushing And Lipid-Associated Disorders Comprising Niacin Receptor Partial Agonists FFAR1, FFAR2, FFAR3 GRM5 685/4885CDK2 3603/4885CTSA 1998/4885
US-20240335448-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE MCL1, TP53, BRDT GRM5 2427/4885CDK2 1060/4885CTSA 317/4885
US-12145924-B2 Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds LPAR1, LPAR2, LPAR5 GRM5 497/4885CDK2 2299/4885CTSA 1428/4885
US-20160220572-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE MCL1, TP53, BRDT GRM5 2427/4885CDK2 1060/4885CTSA 317/4885
US-20120226035-A1 NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF IKZF3, ZC3HAV1L, CXXC5 GRM5 2443/4885CDK2 1841/4885CTSA 3974/4885
US-20230357269-A1 NEW MACROCYCLIC LRRK2 KINASE INHIBITORS LRRK2, RIN1, GRK3 GRM5 1875/4885CDK2 195/4885CTSA 2013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.