Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | DHPS | P49366 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359198 | 0.83 | L3MBTL1 (0.55) | L3MBTL1SMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL2529649 | 0.82 | MRGPRX4 (0.51) | L3MBTL1EGFRSMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL15668510 | 0.82 | ALDH1A1 (0.48) | L3MBTL1SMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL3811355 | 0.82 | TTR (0.58) | L3MBTL1SMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL30222339 | 0.82 | TTR (0.58) | L3MBTL1SMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL121306 | 0.81 | SLC6A4 (0.61) | L3MBTL1EGFRLCKSLC6A4SLC6A2 | |
| SCHEMBL24628562 | 0.80 | SLC6A4 (0.56) | L3MBTL1EGFRLCKCYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL5548964 | 0.80 | TTR (0.57) | L3MBTL1SMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL23095 | 0.79 | MAPT (0.56) | L3MBTL1SMN1; SMN2CYP3A4KDM4EGAA | |
| SCHEMBL29764086 | 0.79 | MAPT (0.56) | L3MBTL1SMN1; SMN2CYP3A4KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-B1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |
| US-8765754-B2 | Pyrrolotriazine compounds | LOCUS PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120232054-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232054-A1 | PYRROLOTRIAZINE COMPOUNDS | BTK, SYK, ZAP70 | L3MBTL1 851/4885EGFR 3296/4885LCK 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.