Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604610 | 0.84 | PLA2G2A (0.56) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL7995915 | 0.84 | PLA2G2A (0.56) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL12101436 | 0.83 | ESR1 (0.59) | TSHR | |
| SCHEMBL2664838 | 0.83 | PLA2G2A (0.54) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL14620895 | 0.81 | PTGS2 (0.59) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL4023882 | 0.79 | POLB (0.64) | TP53TSHRPLA2G4BALDH1A1HPGD | |
| SCHEMBL14232259 | 0.79 | ALDH1A1 (0.58) | TP53TSHRPLA2G4BALDH1A1HPGD | |
| SCHEMBL16645345 | 0.79 | PLA2G2A (0.50) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL1108057 | 0.78 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL1201538 | 0.78 | PLA2G2A (0.66) | PLA2G2ATP53TSHRPLA2G4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010520-B1 | HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PROD INC (US) | 2012-09-12 | — | — | EP | disclosed |