Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29755247 | 0.86 | HSD17B10 (0.45) | HSD17B10ASH1LKIF11ALDH1A1TRPV1 | |
| SCHEMBL7919207 | 0.79 | HSD17B10 (0.54) | HSD17B10ASH1LKIF11ALDH1A1MEN1 | |
| SCHEMBL12110222 | 0.77 | AHR (0.41) | HSD17B10ALDH1A1ARMEN1KMT2A | |
| SCHEMBL18853886 | 0.77 | ALDH1A1 (0.49) | HSD17B10KIF11ALDH1A1MEN1CYP1A2 | |
| SCHEMBL23148126 | 0.75 | HSD17B10 (0.54) | HSD17B10ASH1LKIF11ALDH1A1AR | |
| SCHEMBL22607356 | 0.75 | LMNA (0.34) | HSD17B10ALDH1A1HPGDKMT2AHTR2A | |
| SCHEMBL16076731 | 0.75 | GABRA1 (0.38) | KIF11ALDH1A1 | |
| SCHEMBL2426077 | 0.74 | HSD17B10 (0.53) | HSD17B10ASH1LKIF11ALDH1A1MEN1 | |
| SCHEMBL20028265 | 0.74 | RHEB (0.46) | ALDH1A1HTR2A | |
| SCHEMBL994433 | 0.74 | HSD17B10 (0.53) | HSD17B10ASH1LKIF11ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |
| CN-104039956-A | Method of treatment | GLAXOSMITHKLINE IP NO 2 LTD | 2014-09-10 | — | — | CN | disclosed |
| CN-102970869-B | Indoles | GLAXOSMITHKLINE LLC | 2014-07-16 | — | — | CN | disclosed |
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | MTOR, PIK3CA, PIK3CD | HSD17B10 1661/4885ASH1L 4672/4885KIF11 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.