Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959989 | 1.00 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12111627 | 1.00 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12111656 | 1.00 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12742861 | 0.92 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12742884 | 0.92 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12742881 | 0.92 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12742862 | 0.92 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL13816045 | 0.92 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12112399 | 0.91 | SLC18A2 (0.66) | SLC18A2HTR2AKCNH2 | |
| SCHEMBL12112676 | 0.90 | SLC18A2 (0.65) | SLC18A2HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053578-B2 | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes | GENERAL ELECTRIC COMPANY (US) | 2011-11-08 | — | — | US | disclosed |
| US-7910738-B2 | Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes | GENERAL ELECTRIC COMPANY (US) | 2011-03-22 | — | — | US | disclosed |
| US-20090142265-A1 | ALPHA-FLUOROALKYL TETRABENAZINE AND DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | GENERAL ELECTRIC COMPANY (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143587-A1 | INTERMEDIATES FOR ALPHA-FLUOROALKYL TETRABENAZINE AND DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | GENERAL ELECTRIC COMPANY (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090142276-A1 | ALPHA-FLUOROALKYL DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | GENERAL ELECTRIC COMPANY (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090142276-A1 | ALPHA-FLUOROALKYL DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | CPT1A, DHCR24, VDAC1 | SLC18A2 22/4885HTR2A 416/4885KCNH2 486/4885 |
| US-20090143587-A1 | INTERMEDIATES FOR ALPHA-FLUOROALKYL TETRABENAZINE AND DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | HHAT, COMT, RHOT2 | SLC18A2 6/4885HTR2A 52/4885KCNH2 491/4885 |
| US-20090142265-A1 | ALPHA-FLUOROALKYL TETRABENAZINE AND DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES | DGAT2, DGAT1, TMEM14C | SLC18A2 36/4885HTR2A 461/4885KCNH2 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.