SCHEMBL12113072

SCHEMBL12113072

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Cn2nc3ccc(F)cc3n2)nn1-c1ncccc1Cl

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.34
DHODH Q02127 2/20 0.33
THRB P10828 2/20 0.33
TRPV1 Q8NER1 1/20 0.32
MAPT P10636 1/20 0.32
NTRK1 P04629 3/20 0.32
MALT1 Q9UDY8 3/20 0.32
KMT2A Q03164 2/20 0.32
MET P08581 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12113056 0.93 NPC1 (0.35) DHODHMALT1METHTT
SCHEMBL12113054 0.92 RAB9A (0.33) CHRNA7DHODHMAPTNTRK1MALT1
SCHEMBL12113037 0.92 DHODH (0.36) DHODHNTRK1MALT1MET
SCHEMBL12113059 0.92 DHODH (0.35) DHODHTRPV1NTRK1MALT1MET
SCHEMBL12113079 0.91 SLC2A1 (0.36) CHRNA7
SCHEMBL12113092 0.91 DHODH (0.35) DHODHMALT1METLMNAHTT
SCHEMBL12113053 0.91 DHODH (0.36) DHODHTRPV1NTRK1MALT1KMT2A
SCHEMBL12113057 0.89 PPARG (0.38) THRBMAPTKMT2AMEN1ALDH1A1
SCHEMBL12113173 0.88 DHODH (0.35) DHODHMAPTNTRK1MALT1KMT2A
SCHEMBL12113070 0.88 GRM2 (0.34) CHRNA7DHODHTRPV1NTRK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8536202-B2 Triazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-8536202-B2 Triazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20110275676-A1 Triazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2011-11-10 US disclosed
US-20110275676-A1 Triazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2011-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275676-A1 Triazole-substituted anthranilamides as pesticides AADAC, NAAA, ANTXR2 CHRNA7 708/4885DHODH 3052/4885THRB 978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.