SCHEMBL12117593

SCHEMBL12117593

Cc1cc(-c2cccnc2)ccc1C(=O)Nc1cc(-c2ccccc2)ccc1C(=O)OC(C)(C)C

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MKNK1 Q9BUB5 3/20 0.51
▸ MKNK2 Q9HBH9 3/20 0.51
▸ SLC2A1 P11166 1/20 0.48
▸ HDAC1 Q13547 3/20 0.47
▸ LMNA P02545 1/20 0.46
▸ ABCB1 P08183 5/20 0.46
▸ HDAC3 O15379 1/20 0.46
▸ HDAC2 Q92769 1/20 0.46
▸ ABCC1 P33527 1/20 0.46
▸ HTR6 P50406 1/20 0.43
▸ CYP11B2 P19099 2/20 0.43
▸ CYP19A1 P11511 1/20 0.43
▸ CYP11B1 P15538 1/20 0.43
▸ NTRK1 P04629 1/20 0.43
▸ PDK2 Q15119 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12117635 0.93 LMNA (0.48) MKNK1MKNK2SLC2A1HDAC1LMNA
SCHEMBL12118072 0.91 HDAC1 (0.46) MKNK2HDAC1ABCB1HDAC3HDAC2
SCHEMBL12117652 0.91 HDAC1 (0.48) HDAC1HDAC2
SCHEMBL1317112 0.90 HDAC1 (0.52) MKNK1MKNK2HDAC1LMNAABCB1
SCHEMBL12117634 0.89 HDAC1 (0.53) MKNK1MKNK2HDAC1ABCB1HDAC3
SCHEMBL12118144 0.87 HDAC1 (0.53) HDAC1ABCB1HDAC3HDAC2ABCC1
SCHEMBL12117748 0.86 SLC2A1 (0.45) MKNK1MKNK2SLC2A1HDAC1LMNA
SCHEMBL12117603 0.85 MAPK14 (0.47) HDAC1CYP2C9
SCHEMBL12117928 0.84 HDAC1 (0.48) HDAC1HDAC2
SCHEMBL12117828 0.84 HDAC1 (0.45) HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 MKNK1 3237/4885MKNK2 2960/4885SLC2A1 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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