Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 5/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12122793 | 0.90 | PDPK1 (0.53) | PDPK1AURKBAURKACTSLCTSB | |
| SCHEMBL1318094 | 0.90 | PDPK1 (0.47) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL3126962 | 0.87 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1318419 | 0.87 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL16966440 | 0.87 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1318488 | 0.86 | PDPK1 (0.48) | PDPK1AURKBAURKACTSLCTSB | |
| SCHEMBL12119807 | 0.86 | PDPK1 (0.50) | PDPK1AURKBAURKACTSLCTSB | |
| SCHEMBL12119114 | 0.86 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119499 | 0.86 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119301 | 0.85 | PDPK1 (0.54) | PDPK1AURKBAURKAROCK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PDPK1 12/4885AURKB 262/4885AURKA 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.