Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287516 | 0.83 | CCR3 (0.63) | CCR3SIGMAR1DOCK5OPRL1BCHE | |
| SCHEMBL19147351 | 0.77 | ALDH1A1 (0.50) | SIGMAR1OPRL1ALDH1A1POLBTSHR | |
| SCHEMBL735073 | 0.75 | ALDH1A1 (0.54) | CCR3SIGMAR1OPRL1ALDH1A1POLB | |
| SCHEMBL735072 | 0.75 | ALDH1A1 (0.54) | CCR3SIGMAR1OPRL1ALDH1A1POLB | |
| SCHEMBL29087415 | 0.74 | CCR3 (0.61) | CCR3SIGMAR1OPRL1POLBDRD4 | |
| SCHEMBL14702321 | 0.74 | ALDH1A1 (0.53) | SIGMAR1OPRL1ALDH1A1POLBTSHR | |
| SCHEMBL4481641 | 0.74 | OPRL1 (0.54) | CCR3SIGMAR1OPRL1ALDH1A1POLB | |
| SCHEMBL5155047 | 0.74 | OPRL1 (0.54) | CCR3SIGMAR1OPRL1ALDH1A1POLB | |
| SCHEMBL16659923 | 0.74 | OPRL1 (0.54) | CCR3SIGMAR1OPRL1ALDH1A1POLB | |
| SCHEMBL653218 | 0.74 | CCR3 (1.00) | CCR3SIGMAR1OPRL1POLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058287-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20090281081-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281081-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | ACKR3, CCL11, CCR7 | CCR3 22/4885SIGMAR1 749/4885DOCK5 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.