Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140912 | 0.87 | KMT2A (0.68) | LMNAALDH1A1HPGDMAPTTAAR1 | |
| Hydrochloric Acid SCHEMBL22614720 | 0.86 | KMT2A (0.71) | LMNAALDH1A1HPGDMAPTTAAR1 | |
| SCHEMBL13913702 | 0.83 | KMT2A (0.78) | LMNAALDH1A1KMT2AMEN1CHRM2 | |
| SCHEMBL12123658 | 0.80 | HTR1A (0.56) | LMNAALDH1A1HPGDMAPTTAAR1 | |
| SCHEMBL1140551 | 0.79 | ALDH1A1 (0.68) | LMNAALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL12123614 | 0.77 | ALDH1A1 (0.71) | LMNAALDH1A1HPGDMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL7929096 | 0.76 | TSHR (0.62) | LMNAALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL12123790 | 0.75 | ALDH1A1 (0.73) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7932182 | 0.74 | ALDH1A1 (0.74) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL10537607 | 0.73 | KMT2A (0.62) | LMNAALDH1A1HPGDMAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PHARMACYCLICS INC (US) | 2015-10-15 | — | — | US | disclosed |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2011-11-17 | — | — | US | disclosed |
| US-20070293499-A1 | Intracellular Kinase Inhibitors | MANNKIND CORPORATION (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293499-A1 | Intracellular Kinase Inhibitors | PI4KB, BTK, LTK | LMNA 4556/4885ALDH1A1 4370/4885HPGD 4547/4885 |
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | LMNA 4556/4885ALDH1A1 4370/4885HPGD 4547/4885 |
| US-20110281850-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | LMNA 4556/4885ALDH1A1 4370/4885HPGD 4547/4885 |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | LMNA 4556/4885ALDH1A1 4370/4885HPGD 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.