Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22614720 | 0.99 | KMT2A (0.71) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL12123736 | 0.87 | LMNA (0.64) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL12123658 | 0.84 | HTR1A (0.56) | KMT2AALDH1A1LMNAGAAMAPT | |
| SCHEMBL6405297 | 0.84 | ALDH1A1 (0.70) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL6400287 | 0.82 | ALDH1A1 (0.68) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL17549666 | 0.80 | SIGMAR1 (0.73) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL16026463 | 0.79 | KMT2A (0.83) | KMT2AALDH1A1SIGMAR1MAPTGFER | |
| SCHEMBL12859265 | 0.78 | KMT2A (0.64) | KMT2AALDH1A1LMNASIGMAR1MAPT | |
| SCHEMBL11226725 | 0.78 | SIGMAR1 (0.66) | KMT2AALDH1A1LMNAGAASIGMAR1 | |
| SCHEMBL6399721 | 0.78 | ALDH1A1 (0.62) | KMT2AALDH1A1LMNAGAASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350045-B2 | Process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene and acid addition salts thereof | HIKAL LIMITED (IN) | 2013-01-08 | — | — | US | disclosed |
| US-20110046384-A1 | PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL) - 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF | HIKAL LIMITED (IN) | 2011-02-24 | — | — | US | disclosed |
| EP-2222640-A1 | A PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL)- 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF | Hikal Limited (IN) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009084035-A1 | A PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL)- 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF | HIKAL LIMITED (IN) | 2009-07-09 | — | — | WO | disclosed |
| WO-2007141803-A2 | A PROCESS FOR THE SYNTHESIS OF (E) -2-[1 - (4 - METHYL PHENYL) -3-(1-PYRRONYL)-1 - PROPENYL] PYRIDINE (TRIPROLIDINE) | VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION (IN) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046384-A1 | PROCESS FOR PREPARATION OF E-ISOMER OF 1-(4-METHYLPHENYL) - 1-(2-PYRID YL)-3-PYRROLIDINO PROP-1-ENE AND ACID ADDITION SALTS THEREOF | ENPP1, ELP1, ECE1 | KMT2A 2095/4885ALDH1A1 179/4885LMNA 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.