Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.51 |
| ▸ | MDM4 | O15151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5972648 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2BACE1CASP3 | |
| SCHEMBL30538853 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2BACE1CASP3 | |
| SCHEMBL29460482 | 0.92 | MDM2 (0.54) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL21639223 | 0.92 | MDM2 (0.54) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL29400885 | 0.92 | MDM2 (0.54) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL6273699 | 0.92 | MDM2 (0.54) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL12744189 | 0.87 | MDM4 (0.52) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL3212833 | 0.87 | MDM4 (0.52) | KIF11MDM4TP53MDM2CASP3 | |
| SCHEMBL18308624 | 0.86 | KIF11 (0.41) | KIF11MDM4TP53MDM2BACE1 | |
| SCHEMBL30474408 | 0.85 | MDM4 (0.46) | MDM4TP53MDM2BACE1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586570-B2 | Sox-based kinase sensor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-11-19 | — | — | US | disclosed |
| US-20110281290-A1 | SOX-BASED KINASE SENSOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110281290-A1 | SOX-BASED KINASE SENSOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-11-17 | — | — | US | disclosed |
| US-7964729-B2 | Sox-based kinase sensor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-06-21 | — | — | US | disclosed |
| US-7964729-B2 | Sox-based kinase sensor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-06-21 | — | — | US | disclosed |
| WO-2008082715-A2 | SOX-BASED KINASE SENSOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-07-10 | — | — | WO | disclosed |
| US-20080050761-A1 | Sox-based kinase sensor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2008-02-28 | — | — | US | disclosed |
| US-20080050761-A1 | Sox-based kinase sensor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080050761-A1 | Sox-based kinase sensor | SOX18, HIPK1, HIPK3 | KIF11 3044/4885MDM4 1262/4885TP53 1093/4885 |
| US-20110281290-A1 | SOX-BASED KINASE SENSOR | SOX18, HIPK1, HIPK3 | KIF11 3044/4885MDM4 1262/4885TP53 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.