Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136748 | 0.82 | RAB9A (0.59) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL12136750 | 0.78 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL14075262 | 0.78 | SMN1; SMN2 (0.62) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL12136829 | 0.78 | MEN1 (0.48) | RAB9ASMN1; SMN2NPC1TP53MEN1 | |
| SCHEMBL9805357 | 0.78 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL4916806 | 0.78 | SCD (0.59) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL12136754 | 0.77 | RAB9A (0.60) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL10661558 | 0.77 | RAB9A (0.74) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL9723816 | 0.77 | RAB9A (0.97) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 | |
| SCHEMBL10348208 | 0.77 | RAB9A (0.78) | RAB9ASMN1; SMN2NPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | GLI1, SHH, SMO | RAB9A 990/4885SMN1; SMN2 2484/4885NPC1 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.