Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | PLK1 | P53350 | 12/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.58 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136748 | 0.87 | RAB9A (0.59) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL14075268 | 0.87 | PLK1 (0.75) | PLK1PLK3KCNK2MEN1PKM | |
| SCHEMBL14075264 | 0.84 | PLK1 (0.69) | SMN1; SMN2PLK1PLK3KCNK2MEN1 | |
| SCHEMBL12136754 | 0.79 | RAB9A (0.60) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL12136749 | 0.78 | RAB9A (0.63) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9805357 | 0.78 | RAB9A (1.00) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL9723816 | 0.77 | RAB9A (0.97) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10662853 | 0.77 | RAB9A (0.97) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL14075266 | 0.76 | PLK1 (0.78) | SMN1; SMN2NPC1RAB9APLK1PLK3 | |
| SCHEMBL10772505 | 0.74 | RAB9A (0.66) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |