Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | GCG | P01275 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136826 | 0.83 | RXFP1 (0.50) | MEN1KMT2AGCGNPC1RAB9A | |
| SCHEMBL14372263 | 0.82 | MEN1 (0.50) | MEN1LMNAKMT2APTPN1PTPN2 | |
| SCHEMBL12136827 | 0.79 | MAPT (0.47) | MEN1KMT2ALCK | |
| SCHEMBL12136749 | 0.78 | RAB9A (0.63) | MEN1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL12136828 | 0.78 | RAB9A (0.46) | MEN1LMNAKMT2AGCGNPC1 | |
| SCHEMBL25790388 | 0.67 | PARP1 (0.40) | LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12376611 | 0.67 | BAZ2B (0.60) | PTPN1PTPN2PTPN6PTPN11NPC1 | |
| SCHEMBL14083014 | 0.67 | RAB9A (0.55) | MEN1KMT2APTPN1PTPN2PTPN6 | |
| SCHEMBL5934676 | 0.65 | PTPN1 (0.61) | LMNAPTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL30962898 | 0.64 | TYK2 (0.63) | MEN1LMNAKMT2ATYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | GLI1, SHH, SMO | MEN1 2398/4885LMNA 4471/4885KMT2A 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.