Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | PDXK | O00764 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.45 |
| ▸ | LATS1 | O95835 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12137683 | 0.89 | PTGS2 (0.46) | DHFRPTGS2SCDPIK3CAPIK3CB | |
| SCHEMBL27612333 | 0.83 | ADORA1 (0.61) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12137918 | 0.79 | PTGS2 (0.54) | DHFRPTGS2GHSR | |
| SCHEMBL12135584 | 0.78 | CA12 (0.46) | DHFRPTGS2SCDPIK3CAMTOR | |
| SCHEMBL12137707 | 0.78 | HEXA (0.57) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12138076 | 0.78 | PIK3CG (0.50) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL27631682 | 0.77 | ADORA1 (0.61) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL27631513 | 0.77 | PIK3CG (0.59) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12137855 | 0.76 | DHFR (0.56) | DHFRPIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3452763 | 0.75 | PTGS2 (0.56) | DHFRPTGS2ADORA1ADORA2AGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281838-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281838-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | DHFR 11/4885PTGS2 2504/4885SCD 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.