Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.50 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451799 | 0.84 | ADORA2A (0.52) | ADORA2AADORA1DHFR | |
| SCHEMBL3450840 | 0.84 | ADORA1 (0.52) | ADORA2AADORA1DHFR | |
| SCHEMBL3449845 | 0.84 | ADORA1 (0.65) | ADORA2AADORA1 | |
| SCHEMBL3451401 | 0.83 | ADORA2A (0.51) | PTGS2PTGS1ADORA2AADORA1 | |
| SCHEMBL3450725 | 0.81 | ADORA1 (0.49) | PTGS2PTGS1ADORA2AADORA1DHFR | |
| SCHEMBL3450978 | 0.80 | TSHR (0.51) | ADORA2AADORA1DHFR | |
| SCHEMBL8044562 | 0.77 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL4535505 | 0.76 | HRH4 (0.47) | PTGS2PTGS1ADORA2AADORA1DHFR | |
| SCHEMBL12137709 | 0.75 | DHFR (0.47) | PTGS2GHSRADORA2AADORA1DHFR | |
| SCHEMBL3450769 | 0.75 | ADORA1 (0.52) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820654-B2 | Pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-10-26 | — | — | US | disclosed |
| US-20060084645-A1 | Novel pyrimidine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084645-A1 | Novel pyrimidine compounds, process for their preparation and compositions containing them | UMPS, DPYD, TYMS | PTGS2 1220/4885PTGS1 621/4885GHSR 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.