Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1370059 | 0.85 | ACHE (0.36) | JAK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL1370055 | 0.85 | ACHE (0.36) | JAK2JAK1JAK3 | |
| SCHEMBL1350503 | 0.84 | DGAT1 (0.36) | JAK2JAK1JAK3LMNAMAPT | |
| SCHEMBL12146510 | 0.82 | JAK2 (0.43) | JAK2JAK1JAK3 | |
| SCHEMBL1372179 | 0.82 | JAK2 (0.49) | JAK2JAK1JAK3HRH3 | |
| SCHEMBL1370713 | 0.79 | JAK2 (0.41) | JAK2JAK1JAK3 | |
| SCHEMBL12133508 | 0.77 | DGAT1 (0.39) | — | |
| SCHEMBL12300503 | 0.74 | DGAT1 (0.36) | — | |
| SCHEMBL29489019 | 0.74 | DGAT1 (0.43) | — | |
| SCHEMBL1350460 | 0.74 | DGAT1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |