SCHEMBL12154282

SCHEMBL12154282

C=CC(=O)COc1ccc(C(=O)Oc2ccc(-c3ccc(-c4ccc(OC(=O)c5ccc(OCOC(=O)C=C)cc5)cc4)cc3F)cc2)cc1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.31
THRB P10828 3/20 0.31
SRD5A2 P31213 2/20 0.31
MAPT P10636 5/20 0.31
KMT2A Q03164 2/20 0.31
FYN P06241 1/20 0.31
FEN1 P39748 2/20 0.30
TDP1 Q9NUW8 1/20 0.30
SENP1 Q9P0U3 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
RARG P13631 1/20 0.30
RARA P10276 1/20 0.30
RARB P10826 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12154262 0.89 THRB (0.38) TP53THRBSRD5A2MAPTKMT2A
SCHEMBL12154274 0.89 THRB (0.38) TP53THRBSRD5A2MAPTKMT2A
SCHEMBL12154275 0.89 SLC2A1 (0.36) TP53THRBSRD5A2MAPTKMT2A
SCHEMBL12567687 0.89 SRD5A2 (0.32) THRBSRD5A2MAPTKMT2AFYN
SCHEMBL12154265 0.87 MAPT (0.34) TP53THRBMAPTKMT2ATDP1
SCHEMBL12154281 0.87 EGFR (0.38) TP53THRBSRD5A2MAPTFYN
SCHEMBL17754348 0.87 SRD5A2 (0.35) TP53THRBSRD5A2MAPTKMT2A
SCHEMBL12733720 0.85 THRB (0.40) THRBFYNFEN1RARARARB
SCHEMBL13913494 0.85 THRB (0.40) THRBMAPTKMT2ASMN1; SMN2
SCHEMBL12242463 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8425988-B2 Polymerizable liquid crystal compound, polymerizable liquid crystal composition and anisotropic polymer JNC CORPORATION (JP) 2013-04-23 US disclosed
US-8048496-B2 Polymerizable liquid crystal compound, liquid crystal composition and polymer JNC CORPORATION (JP) 2011-11-01 US disclosed
US-20110147657-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND ANISOTROPIC POLYMER CHISSO CORPORATION (JP) 2011-06-23 US disclosed
US-20100096591-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND POLYMER CHISSO CORPORATION 2010-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100096591-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND POLYMER PKN1, ZYX, OXER1 TP53 4636/4885THRB 3732/4885SRD5A2 116/4885
US-20110147657-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND ANISOTROPIC POLYMER SSB, LEF1, UACA TP53 3618/4885THRB 4550/4885SRD5A2 1707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.